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The strongest builds in How Many Dudes combine family synergies with relic support. The most consistent deep-run build is Viking + Necromancer + Spartan + Cleric, reported to reach wave 120+ in Endless mode. The Zombie + Necromancer Undead core scales damage infinitely as allies fall in battle. The Wizard + Cleric Fantasy core leverages Bloody Talisman and Clerical Error relics for a healing-to-damage feedback loop. For new players, Medic + Paladin + Bard provides a stable foundation while learning the game's economy and relic systems.

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